摘要
目的观察妥泰和尼莫地平对儿童偏头痛发作的预防和治疗作用,并比较其差异。方法将64例偏头痛患者随机分为妥泰组(32例),尼莫地平组(32例),规则、足量的分别使用妥泰、尼莫地平,疗程3个月,观察两组治疗前后每月头痛次数、头痛天数、头痛强度和头痛指数的变化情况。结果妥泰组和尼莫地平组每月头痛次数、头痛天数、头痛强度和头痛指数治疗前后分别自身对照比较均有明显的减少和降低,差异非常显著(t=13.616～17.047;8.143～21.298,P<0.01);而妥泰组与尼莫地平组治疗后相比较,前者的每月头痛次数、头痛天数及头痛强度和头痛指数均较尼莫地平组低,差异显著(t=1.900～2.485,P<0.05～0.01)。结论妥泰和尼莫地平对儿童偏头痛发作均有较好的预防和治疗作用,但妥泰的效果可能比尼莫地平更好。
Objective To evaluate the prophylaxis and treatment effect of topiramate and to nimodipine in pediatric migraine, and compare with the differences.Methods Sixty-four patients with a diagnosis of migraine were randomly assigned to topiramate (n=32) and nimodipine (n=32) groups. The medicine treatment regularly and sufficiently lasted for 3-month treatment phase. The outcome parameters examined included a mean monthly migraine frequency, number of headache days/month, migraine severity and migraine index.Results The mean±SD monthly migraine frequency, number of headache days/month, migraine severity and migraine index decreased significantly in two groups after treatment than before,respectively,and the difference is statistically significant (t=13.616-17.042;8.143-21.298,P<0.01). The above parameters decreased significantly in the topiramate group than that in nimodipine group,and the difference is also statistically significant(t=1.899-2.485,P<0.05-0.01).Conclution Both topiramate and nimodipine are potentially effective prophylaxis and treatment for children with migraine episodes, while the effect of topiramate may be especially better.
出处
《重庆医学》
CAS
CSCD
2005年第5期706-707,710,共3页
Chongqing medicine
关键词
妥泰
尼莫地平
偏头痛
topiramate
nimodipine
migraine
