摘要
感染美洲钩虫成虫的仓鼠口服阿苯达唑７５或１５０ｍｇ／ｋｇ的有效率为８３．８％和１００％。治前３ｄ，２个治疗组每鼠每ｇ粪便培养的幼虫数为２９７１６±３２９９和２８２５６±１１８，对照组的为８８２８±２６５９。治后３ｄ，治疗组的粪便培养未查见幼虫，而对照组的为９０６６±７４１６。此外，受治２组的培养粪便残渣用饱和盐水漂浮虫卵时，无或仅查见几个变性虫卵。仓鼠于感染第３期幼虫后３、７或１４ｄ口服１剂阿苯达唑１５０或３００ｍｇ／ｋｇ时，粪便虫卵阳性率为０－９．１％，减虫率为９６．８－１００％。
When golden hamsters infected with adult Necator americanus were treated ig with albendazole(Alb) 75 or 150 mg / kg ,the efficacy rates were 83.8% and 100% ,respectively.Three days before treatment,the mean numbers of larvae recorded from the incubation of feces from 2 treated groups were 29 716 ± 3 299 and 28 256 ± 118 per gram of feces,while in the control group,it was 8 828 ± 2 659 .Within 3 days after treatment,no larva was detected in the 2 treated groups, but in the control group the mean larva number was 9 066 ± 7 416 .Furthermore,in 2 treated groups none or only a few degenerated eggs could be found using saturated saline solution method.when infected golden hamsters were treated ig with Alb at a single dose of 150 or 300 mg / kg on day 3,7 or 14 after infection with the third stage larvae,the egg positive rates in the feces were 0 9.1% ,while the worm reduction rates were 96.8 100% .
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
1994年第3期200-204,共5页
Chinese Journal of Parasitology and Parasitic Diseases
关键词
钩虫
仓鼠
幼虫期
虫卵
阿苯达唑
Necator americanus ,golden hamster,larva stage,egg,albendazole
