摘要
目的 本研究通过检测肝细胞癌组织COX 2 的表达,探讨COX 2 与VEGF和MVD表达之间的关系,初步探讨COX 2在肝细胞癌血管生成的作用。方法 应用免疫组化方法检测了45 例肝细胞癌组织中COX 2和VEGF、MVD的表达。结果 肝癌、癌旁组织和正常肝组织中COX 2 表达阳性率分别为73.3%、81.3%和100%。高分化癌组织中COX 2蛋白的表达显著高于中分化和低分化癌组织中的表达(P<0.05);癌组织中COX 2 蛋白表达与年龄、性别、肿瘤大小、包膜、门静脉癌栓、AFP均无显著性差异(P>0.05)。COX 2 与VEGF表达和MVD有显著相关性(P<0.01,P< 0.05)。结论 COX 2可通过增加VEGF的表达而促进肿瘤血管的生成。
Objective This study was designed to investigate the expression and significance of COX-2 and the relationship between COX-2 and VEGF in hepatocellular carcinoma. Methods The expression of COX-2 and VEGF were determined by immunohistochemical method in the samples of hepatocellular carcinoma.Results The rate of positive expression COX-2 was 73.3%, 81.3% and 100% in HCC tissues with adjacent nontumorous livers and normal hepatic tissue. The well differentiated HCC expressed that the COX-2 protein was stronger than the moderate and poor differentiate HCC(P< 0.05). There was no significant relationship between the intensity of COX-2 expression and age, sex, tumor size, tumorcapsule, presence of portal vein thrombosis and the level of fetoprotein (P> 0.05). COX-2 expression was significantly correlated with VEGF expression (P< 0.01) and tumor MVD(P< 0.05) in hepatocellular carcinoma.Conclusion COX-2 may stimulate angiogenesis through VEGF upregulation.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2005年第4期199-201,F002,共4页
Cancer Research on Prevention and Treatment
