摘要
作者测试了矽尘作业工人和对照组血超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）的活性变化，结果是矽尘组和对照组ＳＯＤ和ＧＳＨ－Ｐｘ的活性分别为２．３９６±０．４１３（×１０￣３Ｕ／ｇＨｂ），３５．０６±６．９４（μｍｏｌＧＳＨ被氧化量／ｍｉｎ·ｇＨｂ）和２、０９８±０．５９１（×１０￣３Ｕ／ｇＨｂ）、２７．４１±９．２０（μｍｏｌＧＳＨ被氧化量／ｍｉｎ·ｇＨｂ），前者均显著高于后者。同时ＳＯＤ和ＧＳＨ－ＰＸ活性高尘龄组也显著高于低尘龄组。揭示长期接触矽尘，体内的脂质过氧化和抗过氧化活性均处于亢奋状态。抗脂质过氧化的增强，可能是机体的一种防御性机制，是矽尘作业者机体对二氧化硅细胞毒性作用的不同阶段的反应。
he activities of superoxide dismutase(SOD)and glutathione peroxidase (GSH-Px)were
measured in the blood of workers ex-posed to silicious dust. The results showedthat the values
of the activities of SOD ,GSH-Px were 2.396 + 0.413 (10￣3U/gHb) and 35.06+6.94(μmol GSH
oxidized/min·gHb) respec-tively. These were significantly higher thanthat of controls with
2.098±0.591 (10￣3U/gHb)of SOD and 27.41 + 9.20(μmol GSH oxidizied/min gHb),and the
activities of SOD, GSH-Px in the long dust exposing group were alsosignificantly higher than
that of the short period of dust-exposing group. It indicatedthat the activities of lipidperoxide
and antili-pidperoxide were both in active status in the people exposing to silicious dust for
long time.The increase of the latter may be a defensivemeehanism of the body,a response to
thecytotoxicity of SiO-2 in different phases.
出处
《中国工业医学杂志》
CAS
1994年第2期78-80,共3页
Chinese Journal of Industrial Medicine
关键词
矽尘
超氧物歧化酶
过氧化脂质
silicious dust,
superoxidedismutase(SOD),glutathione peroxidase(GSH-Px)
