摘要
以含硒量低于０．０１２μｇ／ｇ的饲料喂养Ｗｉｓｔａｒ大鼠，形成低硒动物模型，用膜片箝技术记录动物模型心肌细胞的钾通道活动。用丹酚酸Ａ或亚硒酸钠可激活钾通道开放。用黄嘌呤／黄嘌呤氧化酶产生氧自由基作用于细胞膜可明显抑制钾通道开放。
The animal model of Selenium deficient rat was set up by feeding Wistar rat with food containing Selenium lower than 0. 012μg/g. Potassium channel currents in single cardiac myocyte of Selenium deficient rat were recorded,using Patch-clamp techniques. Salvianolic acid A or sodium selenite activated potassium channels. Oxygen free radicals generated from reaction of xanthine and xanthine oxidase affected cell membrane and inhibited opening of potassium channels evidently.
出处
《中国地方病学杂志》
CAS
CSCD
1994年第3期142-145,共4页
Chinese Jouranl of Endemiology
关键词
钾通道
丹酚酸A
硒
心肌细胞
Selenium deficient rat Potassium channels Salvianolic acid A Selemum
