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脱碘酶活性改变在克山病发病机制中的作用 被引量:3

Effect on pathogenesis of Keshan Disease by change of thyroxine 5'-monodenase activity
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摘要 本文测定了饲克山病病区粮大鼠心、肝、肾、甲状腺T.5'-脱单碘酶活性。结果表明病区粮组大鼠心、肝、肾组织中的脱碘酶活性明显降低,并在补硒、维生素E后可使脱碘酶活力恢复正常。提示脱碘酶活性的改变在克山病发病中可能起着重要的作用。 In this paper,writers investigate the activities of myocardial hepatic and renal thyroxine 5' monodiodinose of rats fed with grains from a KD endemic area. The results showed that myocardral,hepatic and renal thyroxine 5'-monodeiodinose activities were significantly reduced in rats fed with grains from a endemic area. This enzyme activity was effectively enhanced through Se or/and VE supplementation to the diet. It suggested that changes of Thyroxine 5'-monodeiodinase activity may play an important role in Keshan Disease attack.
出处 《中国地方病学杂志》 CAS CSCD 1994年第2期77-79,共3页 Chinese Jouranl of Endemiology
基金 国家自然科学基金霍英东教育基金
关键词 克山病 脱单碘酶 病因 Keshan Disease T_4 5'-monodeiodinase
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