摘要
目的探讨血清胃泌素与胃癌患者腹泻的关系。方法本文对21例伴腹泻症状,27例不伴腹泻症状的胃癌患者进行了血清胃泌素浓度放免测定和免疫组化学研究。结果血清胃泌素浓度在21例伴腹泻胃癌患者为(167.68±61.54)Pg/ml,在27例不伴腹泻胃癌患者为(63.82±30.18)Pg/ml,P<0.05。在34例正常对照者为(48.94±28.72)Pg/ml。胃泌素型癌细胞发现率在腹泻组为28.57%(6/21),无腹泻组为18.52%(5/27),P>0.05。癌旁G细胞计数在腹泻组为(248.56±77.24)个/mm2,无腹泻组为(169.72±42.94)个/mm2,P<0.05;正常人胃窦G细胞计数为(178.34±53.16)个/mm2。结论高胃泌素与胃癌患者的腹泻产生有关,高胃泌素血症来源可能是癌旁G细胞增生。
Objective To study the realtion between gastrin and diarrhea in gastric cancer patients.Methods Radioimmunoassay was used to determine the serum concentration of gastrin ,immunochemical stainning was also performed in 21 cases with diarrhea and 27 cases without diarrhea.Results Serum gastrin concentration in the 21 cases gastric cancer patients with diarrhea was (167.68±61.54)pg/ml,in the 27 patients without diarrhea,the result was (63.82±30.18)pg/ml(P<0.05),while in our 34 cases of control group,gastrin concentration was (48.94±28.72)pg/ml.Gastrin-type concer cell in 6 of the 21 patients in diarrhea group (28.57%), in the non-diarrea group the rate was 18.52%(5/27)(P>0.05).G-cell calculation of peri-carcinoma specimen was (248.56±77.24)/mm^2 in diarrhea group,(169.72±42.94)/mm^2 in non-diarrhea group(P<0.05),and (178.34±53.16)/mm^2 in the control.Conclusion High serum gastrin concentration was correlated to diarrhea in gastric cancer patients,and the high gastrin level may be the result of G-cell hyperplasia in peri-carcinoma tissue.
出处
《医药论坛杂志》
2005年第6期15-16,共2页
Journal of Medical Forum
关键词
胃癌
腹泻
G细胞
Gastric cancer
Diarrhea
G-cell
