摘要
为了探讨心钠素（ＡＮＦ）对内皮素（ＥＴ）生物学效应的拮抗作用，我们进行了下述实验。在ＥＴ致小鼠死亡实验中，观察到大剂量ＡＮＦ可显著延长小鼠存活时间；在ＥＴ致大鼠升压实验中，观察到ＡＮＦ明显拮抗ＥＴ的升压作用；在大鼠离体胸主动脉环灌流实验中，观察到ＡＮＦ对ＥＴ引起的血管收缩呈浓度依赖的舒张作用；在培养的血管平滑肌细胞中，观察到ＡＮＦ显著抑制ＥＴ的促血管平滑肌细胞钙内流作用。结果表明：ＡＮＦ对ＥＴ生物学效应具有部分拮抗作用，ＡＮＦ在治疗与ＥＴ有关的疾病上，可能具有潜在临床意义。
In order to investigate inhibitory effect of atrial natriuretic factor(ANF)on biological action of endothelin(ET),the in vivo and in vitro experiments were taken.It was found that in the experiment of ET-induced death in mice, simultaneous treat-ment with large dose of ANF significantly prolonged animal survival time, and that ad-ministration of ANF to rat obviously inhibited its blood pressure elevation produced by ET.And ANF relaxed isolated perfused rat aortic ring dose-dependently, which were precon-tracted by ET.In cultured vascular smooth muscle cells ANF markedly lowered ET-stimulated Ca￣(2+) influx. These results showed that ANF partly antagonized ET biologicalactions, suggesting that ANF, as an adjuvant to treat diseases related to ET, could haveprespective significance in clinical application.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1994年第2期169-172,共4页
Chinese Journal of Pathophysiology
关键词
钙
内皮素
血管平滑肌
心钠素
血压
Calcium
Endothelin
Vascular smooth muscle
Atrial natriuretic factor
Bloodpressure
