摘要
目的探讨环氧合酶-2(COX-2)和基质金属蛋白酶-2(MMP-2)在骨肉瘤中表达的临床意义。方法采用免疫组织化学方法(S-P法)检测31例骨肉瘤组织标本中COX-2和MMP-2蛋白的表达。结果骨肉瘤组织中COX-2和MMP-2蛋白的阳性率分别为61.30%和54.80%,显著高于对照组骨软骨瘤组织(P<0.05)。COX-2的表达与骨肉瘤组织分级、肺转移有关(P=0.033,P=0.008)。MMP-2的表达与肺转移有关(P=0.019),而与组织分级关系不大(P=0.821)。COX-2的表达与MMP-2的表达密切相关(r=0.007,P=0.008)。二者的表达与患者的性别、年龄无关。结论在骨肉瘤中,COX-2、MMP-2参与肿瘤发生发展过程,并且它们之间具有协同作用。
Objective To investigate the expression of MMP - 2 and COX - 2 in osteosarcoma, as well to explore their relationship and clinical significance. Methods COX - 2 and MMP - 2 were detected by S P immunohistochemical method in 31 cases of paraffin - embedded sections of osteosarcoma. Results The positive rate of COX - 2 and MMP - 2 in human osteosaicoma is 61.30% and 54.80% respectively, which is significantly higher than that in osteochondroma. The expression of COX - 2 is significantly associated with the histological grades,lung metastasis (P = 0.033, P=0.008). The expression of MMP-2 is significantly correlated with lung metastasis (P=0.019), but not with histological grades (P=0.821). There is a significant correlation between the expression of COX-2 and MMP-2 (r =0.007,P= 0.008). Conditions such as age, sex have no relation with the expression of COX -2 and MMP -2. Conclusion COX - 2 and MMP - 2 participate in the carcinogenesis and development of osteosarcoma, and there is synergetic action between them.
出处
《实用肿瘤学杂志》
CAS
2005年第2期91-94,共4页
Practical Oncology Journal
