摘要
目的观察缺氧缺血性脑病(HIE)患儿血浆和脑脊液中的丙二醛含量以及颅脑CT的改变情况。方法利用TBA比色法同步测定各组患儿血浆和脑脊液中丙二醛(MDA)含量,同时适时对各组患儿进行颅脑CT的平扫。结果HIE患儿急性期和恢复期MDA含量均显著高于正常儿,且病情越重MDA含量越高;HIE临床症状越重,CT所表现的脑实质损害也越重,重者多合并颅内出血。各组患儿MDA含量和颅脑CT改变具有高度一致性。结论MDA是反映脑实质损伤的重要指标,而且参与了脑损害过程;颅脑CT改变能更客观地反映HIE患儿的病情轻重,测定MDA的同时做颅脑CT对HIE的早期诊治和判断预后具有重要的意义。
Objective To observe the clinical significance of MDA content in HIE babies′ plasma and cerebrospinal,and the change of the cerebral CT.Methods By means of TBA colorimetric method,we synchronously examine the MDA contents in HIE babies′ plasma and cerebrospinal,and observe the cerebral CT at the same time.Results The result indicates that the contents of MDA of HIE babies,either in acute stage or restoration stage,are evidently higher than those of normal babies.The more serious the disease is,the higher the content of MDA is;Meanwhile,the more serious the HIE clinical symptoms ax is,the more severe the brain injury is.Combined intracranial hemorrhage often accompanies a very bad brain injury.The change of contents of MDA and CT in each group has very high uniformity.Conclusion The present experiment proves the fact that MDA is an important index reflecting brain injury.Besides,MDA plays a part in damaging the brain.CT change can reflect more objectively the seriousness of HIE.Testing the content of MDA and having a brain CT examination have great significance in the early diagnosis,treatment and prevention of HIE.
出处
《中国全科医学》
CAS
CSCD
2005年第8期623-624,共2页
Chinese General Practice
