摘要
目的:评价硝酸甘油口腔速崩片与市售含片的药效学。方法:制备与市售含片含量相同的硝酸甘油口腔速崩片,并比较两者对受试者舒张压、心率的影响。结果:服药后3min内,硝酸甘油口腔速崩片的显效速度明显快于市售含片,两者比较具有显著性差异(P<0 .05)。结论:硝酸甘油口腔速崩片的药效与市售含片比较更迅速,更适合急症冠心病患者服用。
OBJECTIVE:To evaluate clinical pharmacodynamics between fast-disintegrating oral nitroglycerin tablets and commercial tablets.METHODS:Fast-disintegrating oral nitroglycerin tablets with the same content as commercial tablets were prepared,the effects of two kinds of tablets on diastolic blood pressure,heart rate of the healthy volunteers were observed and compared.RESULTS:Fast-disintegrating oral nitroglycerin tablets showed more rapid drug absorption than the commercial tablets3minutes after administration,there was remarkable difference between them(P<0.05).CONCLUSION:Fast-disintegrating oral nitroglycerin tablet is more powerful than that of the commercial tablet in respect of pharmacody-namics,therefore is more preferable for patients with acute coronary heart disease or angina pectoris.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第8期606-607,共2页
China Pharmacy
关键词
硝酸甘油
口腔速崩片
市售含片
心率
舒张压
Nitroglycerin
Fast-disintegrating oral tablet
Commercial tablet
Heart rate
Diastolic blood pressure
