摘要
目的:探讨Graves病(GD)用较小剂量131I联合中药治疗前后血清sFas/sFasL(可溶性细胞凋亡因子-1 /sFas配体)变化的规律及其与TRAb的关系。方法: 31例GD患者,用较小剂量131I(85 1~207 2MBq,平均140 6MBq)联合中药进行治疗,用酶联免疫吸附试验(ELISA)检测GD患者治疗前及治疗后不同时期血清sFas与sFasL含量,求出sFas/sFasL,并与正常对照组对比,分析GD患者血清sFas和sFasL含量,求出sFas/sFasL,并与正常对照组对比,分析GD患者血清sFas和sFasL与TRAb的相关关系。结果:①GD患者治疗前sFas(179. 8±64. 2)pg/ml明显高于临床治愈期(104. 2±23. 5)pg/ml,P<0 05和正常对照组(110 6±18. 1)pg/ml,P<0 05,甲低时的sFas(117 0±20. 6)pg/ml与正常对照比无显著性差异。sFasL治疗前(353 8±92 8)pg/ml同样明显高于临床治愈期(261 1±85 3)pg/ml,P<0 05和正常对照组(265 6±62 1)pg/ml,P<0 05。甲低时的sFasL(257 1±55 3)pg/ml与正常对照比无显著性差异。②GD患者治疗前的sFas/sFasL(0 51±0 23)和甲低时(0 46±0 13)皆大于正常对照( 0 41±0 16,P<0 05 )。sFas和sFasL皆与TRAb呈正相关(r分别为0 52和0 49,P<0. 05)。③较小剂量131I联合中药治疗GD近期疗效良好,有效率100% (31 /31),一次性治愈率74 2% (23 /31)。
Objective To investigate the rule of changes of serum sFas/sFasL and TRAb concentrations in patients with Graves’ disease after tretment with lesser dosage of 131 I combined with traditional chinese medication. Methods Thirty-one patients with Graves’ diesease were treated with a lesser dosage (85.1~207.2MBq, mean——about 2/3 of conventional dose) of 131 I combined with traditional chinese medicine. Serum sFas, sFasL (with ELISA), TRAb (with RRA) and other thyroid-related hormones (TT 3, TT 4, FT 3, FT 4, TSH, TGA, TMA with RIA) concentrations were determined before and after the treatment. Seventeen controls participated in this experiment. Results ① Serum sFas contents in the patients before treatment (179.8±64.2pg/ml) were significantly higher than those in patients clinically cured (104.2±23.5pg/ml) and controls (110.6±18.1pg/ml) (both P<0.05). Serum sFas contents in those patients (n=10) renderd hypothyroid after treatment (117.0±20.6pg/ml) were not much different from those in controls. Serum sFasL contents before treatment (353.8±92.8pg/ml) were also significantly higher than those in patients cured (261.9±85.3pg/ml) and controls (265.6±62.1pg/ml) (both P<0.05). Again, serum sFasL contents in patients rendered hypothyroid (257.1±55.3pg/ml) were not much different from those in controls. ② The sFas/sFasL ratios in the patients before treatment (0.51±0.23) and rendered hypothyroid (0.46±0.13) were significantly higher than those in controls (0.41±0.16,both P<0.05). Both sFas and sFasL contents were positively correlated with those of TRAb (r=0.52 and 0.49 respectively, P<0.05). ③ Resul of treatment of Graves’ disease with lesser dosage of 131 I and traditional chinese medicine was satisfactory. The treatment was immediately effective in 100% of the patients (31/31) with a permanant cure rate of 74.2% (23/31) (one dose only) and late hypothyrodism rate of 9.7% (3/31). Conclusion Reversal of the dominant expression of sFas after the combined treatment indirectly
出处
《放射免疫学杂志》
CAS
2005年第2期108-110,共3页
Journal of Radioimmanology
基金
广州市中医药
中西医结合科研课题(200211)
