摘要
目的观察乌司他丁对肝叶切除术患者围术期肝功能的保护作用。方法将临床28例肝癌行肝叶切除术患者,随机分为乌司他丁组(W组)和对照组(C组)。乌司他丁组按1万u/kg,于麻醉诱导后切皮前加入500m L乳酸林格液中静脉滴注。分别于诱导后切皮前(T1),阻断肝门10m in(T),恢复肝血流后20m in2(T),恢复肝血流后1h(T4),术后1d(T),术后3d(T)术后5d(T)抽取静脉血,行血浆谷草转氨酶3567(A LT)、谷丙转氨酶(AST)、总胆红素(TBIL)的测定。结果术后各时点W组的A LT、AST、T BIL均较C组低,其中ALT、A ST在T3、T、T均明显低于C组(P<0.05),TBIL在术后第1天显著低于C组(P<0.05)。45结论乌司他丁对肝叶切除术患者围术期肝功能有保护作用。
To investigate the Protective effects of ulinastatin on liver function in patients undergoing Hepatectomy. Twenty-eight primary patients with hepatic carcinoma scheduled for hepatectomy were divided into two groups of 14 each: controlled group(group C) and ulinastatin group (group W). In group W, patient received ulinastatin 10 000 u/kg. Plasma levers of alanine transaminase(ALT), aspartate transaminase(AST) and total bilirubin (TBIL) were measured before operation (T1), 10 min after hepatic inflow occlusion (T2), 20 min after recovering hepatic inflow (T3), 1h after recovering hepatic inflow (T4), 24 h (T5), 3 days (T6) and 5 days (T7) after operation. In the T2, T3, T4, T5, T6 and T7, the plasma levers of ALT, AST, TBIL were lower in group W than that in C group. The plasma levers of ALT, AST in the T3, T4 and T5 in group W were remarkably lower than those in group C (P <0.05). On the first postoperative day, The plasma levers of TBIL in group W were remarkably lower than those in group C (P <0.05). [Conclusions] It suggest that ulinastatin can effectly protect liver function in patients undergoing hepatectomy.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第7期1046-1047,1050,共3页
China Journal of Modern Medicine
