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生物组织光学参数的校准模型及测量 被引量:6

Phantoms with Tissue-Like Optical Properties for Use in Near-InfraredSpectroscopy and Imaging
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摘要 在intralipid 墨水(ink)液体模型中,通过改变intralipid溶液和墨水的浓度就可以灵活地获得不同的光学参数。制作了一种可以长期重复使用的光学特性稳定的Si树脂模型,它是利用TiO2 粉末作为散射颗粒,同时加入C粉颗粒来改变模型的吸收特。为了验证intralipid 墨水液体模型制作中基于Mie散射理论的近似计算公式,利用多波长的时间分辨(TRS)方法对不同intralipid浓度的液体模型进行了测试。实际测量结果和Mie散射理论计算的误差在5%以内,这可能是由于所作用的intralipid溶液之间的差别造成的。利用频域的相位调制系统(PMD)对Si树脂模型进行了多间距测量,斜率的线性回归拟合结果显示了良好的线性度(R2>0.99),从而保证了光学参数测量结果的准确性。 Intralipid was used for providing the scattering component in a liquid tissue phantom. By diluting intralipid we are able to change the scattering properties of our model. Addition of India ink changes the model absorption. In order to provide a stable and reproducible phantom, a pliable RTV silicon resin model was developed. Titanium oxide and carbon black powders were added to the resin to obtain tissue-like optical properties. Time-resolved spectroscopy (TRS) was employed to obtain experimental values for reduced scattering coefficient for intralipid-ink solution at various wavelengths and we compare these values with those predicted by Mie theory. The 5% difference between our results and the results from Mie thoery is attributed at least in part to a difference in intralipid composition. Good linearity (R2>0.99) is found for the lines used to define the slope of AC component and phase.
出处 《光电子.激光》 EI CAS CSCD 北大核心 2005年第4期496-500,共5页 Journal of Optoelectronics·Laser
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参考文献19

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