摘要
目的:阐明细胞性血管纤维瘤的临床病理形态特征及鉴别诊断。方法:报道1例外阴细胞性血管纤维瘤并进行组织形态学、免疫组织化学研究,结合文献分析本病的临床表现、病理形态特点及鉴别诊断。结果:细胞性血管纤维瘤呈不规则小叶状,瘤细胞呈短梭形,大小一致,核卵圆至梭形,核分裂象不易见;肿瘤含大量的小至中等大小的血管,以无分支的毛细血管为主,血管壁增厚、玻璃样变,可见黏液样基质。免疫组化:瘤细胞Vimentin阳性,而CD34、S- 10 0蛋白、NF、desmin、SM- actin、CK、EMA均阴性。结论:细胞性血管纤维瘤是一种少见的良性软组织肿瘤,好发于女性外阴,起源于纤维母细胞,突出的两个成分是血管和一致性间质细胞。
Objective To study the clinico-pathologic characteristic and differential diagnosis of cellular angiofibroma(CA).Methods With review of the literature, histopathology and immunohistochemistry were used to investigate clinical appearance, pathomorphologic features and differential diagnosis in one case of cellular angiofibroma.Results The tumor was characterized by an irrrgular lobular growth pattern, uniform and short spindled cells with ovoid to fusiform nuclei,numerous small to medium sized blood vessel with thick-walled and pronounced hyalinization. There was few mitotic figures and interstitial myxoid degeneration. Immunohistochemically, the tumor cells were vimetin postive, but non-reactive for CD34, S-100 protein, desmin, CK, and desmin.Conclusions CA is a rare benign soft tissue tumor that chiefly involves the vulval region,and originates from fibroblasts. It's distinctively composed of vessels and uniform mesenchymal cells.
出处
《实用医技杂志》
2005年第04A期891-893,共3页
Journal of Practical Medical Techniques
