摘要
蜱作为人与动物疾病的第二大传播媒介,已受到人们的广泛关注。目前,人们正致力于免疫接种来控制蜱及蜱传疾病,但蜱对宿主产生了一系列的免疫调节作用,为抗蜱免疫接种的实施增加了难度。文章就蜱对宿主的免疫调节方式,减弱淋巴细胞增殖反应,扰乱细胞因子的产生和分泌;阻碍宿主B细胞的增殖与抗体产生;抑制补体旁路的激活;破坏NK细胞的杀伤功能;抑制巨噬细胞引起的炎性反应等方面进行了概述。对目前已发现的一些免疫调节蛋白如IgG结合蛋白(IGBPs)、唾液腺抗补体蛋白(Isac)、IL 2 结合蛋白(IL 2BP)、免疫抑制剂(Iris)等研究状况进行了综述,为抗原的进一步筛选和优化提供参考。
As the second disease transmitting agents transmitting to human and animals, ticks get significant public health concerns. Vaccination has been adopted to control tick and tick-borne diseases at present, however, tick developed a series of countermeasures to mediate host immunity, which affected the effect of vaccination. Immunomodulatory countermeasures such as to weaken the proliferation of lymphocytes, to disturb the produce and secretion of the cytokines, to block the proliferation of B cells and the secretion of antibodies, to restrain the activation of the complement alternative pathway, to destroy the function of NK cells and to inhibit the inflammation reaction of the monocytes were stated in this paper.Several modulatory proteins( IGBPs、Isac、IL-2BP and Iris etc) stndied were also described. For the sake of providing plenty data to obtain and optimize anti-tick vaccine antigens in the future, informations above was favorable.
出处
《动物医学进展》
CSCD
2005年第4期34-38,共5页
Progress In Veterinary Medicine
关键词
蜱
宿主
免疫调节
Tick
host
immunomodulation
