摘要
目的 探讨甘油注射阻滞术治疗三叉神经痛的机制。方法 在慢性压迫性损伤大鼠眶下神经致三叉神经痛模型基础上,经颞下窝入路显露三叉神经半月节,实验组行半月节后根甘油注射阻滞术,对照组注射生理盐水,观察其电镜改变和体感诱发电位变化。结果 甘油注射组神经纤维轴索变性萎缩,神经传导功能明显下降,10周后神经轴索再生。结论 甘油注射阻滞术治疗三叉神经痛可能是通过破坏粗的有髓神经纤维而发挥阻滞作用,这种破坏作用是可逆的。
Objective To study the mechanism of glycerol in treatment of trigeminal neuralgia. Methods After chronic constriction injury was produced to the infraorbital nerve and the model of trigeminal neuralgia in rats was successfully established, the trigeminal ganglion and preganglionic rootlets were exposed through infratemporal fossa approach. In the experimental group, pure glycerol was instilled into the preganglionic rootlets, while in the control group physiologic saline instead. The electrophysiologic response and the results of the electron microscopy were observed at different time points after glycerol injection. Results The latency of sensory evoked potential in the experimental group was longer than that in control group. Under the electron microscope, demyelination and degeneration were very similar in two groups, but disruption of neuraxon was only observed in the experimental group. Neuraxon regeneration occurred 10 weeks later. Conclusion Retrogasserian glycerol rhizotomy in treatment of trigeminal neuralgia was through disruption of myelinated nerve fiber that is reversible.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2005年第8期737-739,共3页
Journal of Third Military Medical University
