摘要
艾他培南是同类结构中唯一非胃肠道给药的碳青酶烯类抗生素,有广泛的抗菌活性,包括革兰阳性与阴性需氧菌和厌氧菌。对临床分离菌,如铜绿假单胞菌、耐酶葡萄球菌和耐甲氧西林的金黄色葡萄球菌(MRSA)和肠球菌有效。临床上用于治疗成人中度至重度敏感菌引起的感染,如:腹腔内感染、皮肤软组织感染、肺炎、复杂的尿路感染、肾盂肾炎和急性盆腔炎。对头孢菌素耐药的超广谱β内酰胺酶(ESBLs)和AmpC型β内酰胺酶及青霉素耐药的肺炎球菌有较强活性。艾他培南蛋白结合率高,血清半衰期为4h,每日1次给药,耐受性好。
Ertapenem sodium(trade name Invanz TM , also designated as MK-826,L-749345) is structurally unique parenteral 1β-methyl carbapenem. It has a broad spectrum of antimicrobial activity, including common community -acquired Gram-positive and Gram-negative aerobic and anaerobic pathogens, and restricted activity again nosocomial pathogens such as Pseudomonas aeruginosa, Acinetobacter species, methicillin-resis-tant staphylococci and entercocci. Ertapenem demonstrates excellent activity against cephalosporin-resistant enteric organisms producing extended spectrum β-lactamasesa(ESBLS) or AmpC β-lactamasesa and excellent activity against Streptococcus pneumoniae. Its high level of protein bonding and serum half-life of 4 h allow it to be dosed once daily. Ertapenem may be administered intravenously or intramuscularly and has an excellent adverse reaction and tolerability profile.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2005年第1期74-78,共5页
The Chinese Journal of Clinical Pharmacology
