摘要
目的 观察免疫吸附对急性吉兰巴雷综合征的治疗效果。方法 对56例急性吉兰巴雷综合征患者分别进行免疫吸附(Immunoadsorption,IA)治疗及常规治疗,治疗前后观察神经功能改善状况,检测治疗前后血液中免疫系列、补体系列及总蛋白。结果 IA组1月后MRC评分与常规治疗组相比有显著性差异,在半年后Hughes评分两组间的差异有显著意义,治疗后血液中的免疫球蛋白IgG、IgA及补体C3 水平明显低于常规治疗组,总蛋白无明显变化。结论 IA是治疗急性吉兰巴雷综合征较为有效的方法,可明显地改善神经功能缺损状况,这可能与降低血液中免疫球蛋白及补体有关。
Objective To observe the effect of acute Guillain Barre syndrome (GBS) treated with immunoadsorption (IA).Methods Fifty six cases with acute GBS were divided into two groups.One group was treated with IA,and the other group was treated with routine treatment.The improvement of neurological function was observed.The immunoglobulin,complement,and total protein in blood were measured before and after therapy.Results There were significant differences in Medical Research Council (MRC) sumscore after 1 month between the IA group and the control group.After half a year,there were also significant differences in Hughes sumscore between the two groups.After therapy,both immunoglobulin IgG and IgA and complement C3 in blood decreased dramatically,compared with the control group.But no distinct difference was found in total protein before and after therapy.Conclusions IA is an effective method in the treatment of acute GBS.The improvement of neurological function was observed.The mechanism is possibly associated with the decrease of immunoglobulin and complement in blood.
出处
《卒中与神经疾病》
2005年第2期107-109,共3页
Stroke and Nervous Diseases
关键词
免疫吸附
吉兰巴雷综合征
免疫球蛋白
补体
Immunoadsorption Guillain-Barre syndrome Immunoglobulin Complement
