摘要
目的分析口腔癌术前化疗及其效果与肿瘤细胞血管内皮生长因子(VEGF)表达等相关因素的关系。方法对近4年来在本院诊断并接受平阳霉素(总量为80mg)化疗的51例口腔癌患者化疗前后肿瘤细胞VEGF表达、化疗期间发热及其持续时间等与疗效进行直线相关和回归分析。结果⑴92.1%(47/51)的口腔癌患者经术前化疗后肿瘤细胞VEGF表达降低,但与化疗效果无明显相关性;⑵化疗前期发热的程度与化疗效果密切相关(P<0.05)。结论化疗使肿瘤细胞的VEGF表达降低但与疗效无关;化疗早期出现的发热可以作为初步判断预期疗效的方法。
Objective To analyze the relationship between the chemotherapeutic efficacy and VEGF expression in the patients with oral squamous cell carcinoma. Methods 51 cases with oral squamous cell carcinoma who received preoperative chemotherapy of a total 80mg pingyangmycin were enrolled in this study. The relationship among the chemotherapeutic effect, VEGF expression, fever, and the duration of fever was analyzed using linear correlation, stepwise regression and student t-test. Results VEGF expression in the cancer cells of 92.1%(47/51) patients decreased after preoperative chemotherapy, and the decreased expression of VEGF was not significantly correlated with chemotherapentic efficacy. But the chemotherapeutic effect was closely related with fever degree in the early stage of chemotherapy. Conclusion There was no significant relationship between chemotherapeutic effects and VEGF expression in oral squamous cell carcinoma. Fever in early stage of chemotherapy may serve as an index for evaluating the patient prognosis.
出处
《中国医师杂志》
CAS
2005年第4期481-483,共3页
Journal of Chinese Physician
基金
湖南省科委基金编号D3SSY3027
