摘要
目的研究急性心肌梗死(acutemyocardialinfarction,AMI)伴左心力衰竭患者经皮冠状动脉介入治疗(PCI)后心钠素(atrialnatriureticpeptide,ANP)和脑钠素(brainnatriureticpeptide,BNP)二种因子的变化及其临床意义。方法入选AMIKillipⅡ级患者40例作为试验组,在AMI1周内行PCI治疗,另入选AMIKillipⅡ级未行PCI治疗患者40例作为对照组。试验组患者于AMI48h内,PCI术后24h,术后1个月时,对照组患者在相对应的时间,采集肘静脉血,采用酶联免疫吸附法分析,测血浆ANP及BNP水平。结果两组间ANP、BNP水平比较,试验组患者AMI48h内,血浆ANP、BNP水平均与对照组相似,两者间无显著性差异(P>0.05)。PCI术后24h,术后1个月ANP、BNP水平均较对照组明显降低,两组间有显著性差异(P<0.05);组内比较,试验组患者PCI术后24hANP、BNP水平较AMI48h内减低,但两者间无显著性差异(P>0.05);PCI术后1月ANP、BNP水平较术前明显回落,两者有显著性差异(P<0.05)。对照组患者在相对应的PCI术后24h,术后1个月这一时限ANP、BNP水平较AMI48h内无明显变化(P>0.05)。结论本研究发现AMIKillipⅡ级患者经PCI治疗可使血浆ANP、BNP水平降低。
Objective To determine the plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) change in patients with acute myocardial infarction (AMI) in Killip classesⅡ underwent percutaneous coronary intervention (PCI). Methods 40 consecutive patients with AMI in Killip classesⅡ were studied prospectively, other 40 patients with AMI in Killip classesⅡact as control. Blood samples were withdrawn at AMI 48 hours, 24 hours after PCI and 1 month after PCI. Soluble ANP and BNP levels were assayed at presentation. Results The levels of ANP and BNP of trial group were similar to control group at AMI 48 hour, but that decreased after PCI in trial patients. Only the levels of ANP and BNP at 1 month after PCI were significantly lower than AMI 48 hour(P<0.05). In control group there were no difference at that times. Conclusion The levels of ANP and BNP in patients with AMI in Killip classesⅡwere significantly decreased after PCI.
出处
《中国心血管杂志》
2005年第2期109-110,共2页
Chinese Journal of Cardiovascular Medicine
关键词
急性心肌梗死
心钠素
脑钠素
经皮冠状动脉成形术
Acute myocardial infarction
Atrial natriuretic peptide
Brain natriuretic peptide
Percutaneous coronary intervention
