摘要
目的探讨血浆6 酮前列腺素F1α(6 酮PGF1α)、8 表氧前列腺素F2α(8 表氧PGF2α)和11 去氢血栓烷B2(DH TXB2)水平在糖尿病肾病(DN)中的变化及临床意义。方法对68 例DN患者和20例正常对照进行血浆6 酮PGF1α、8 表氧PGF2α和DH TXB2 等检测,分别分析其与尿白蛋白分泌率(UAER)的相关关系。结果DN各组血浆8 表氧PGF2α、DH TXB2 水平均显著高于对照组(P<0 01),且临床期DN组(CDN)高于早期DN组(EDN)(P<0 05);血浆6 酮PGF1α水平显著低于对照组(P< 0 05),且CDN组低于EDN组(P< 0 05);血浆DH TXB2 (r= 0 4391,P<0 05)和8 表氧PGF2α(r=0 4831,P<0 05)均与UAER呈正相关,而血浆6 酮PGF1α与UAER呈负相关(r=-0 3892,P<0 05)。结论血管内皮损伤、血小板活化和脂质过氧化是DN发生、发展的重要机制。
Objective To investigate the clinical significance of plasma 6-keto-prostaglandin F_~1α (6-keto-PGF_~1α ),8-epi-prostaglandin F_~2α (8-epi-PGF_~2α )and 11-dehydrothromboxane B_2(DH-TXB_2)in patients with diabetic nephropathy(DN).Methods The plasma 6-keto-PGF_~1α ,8-epi-PGF_~2α and DH-TXB_2 levels of DN patients (n=68) and normal controls(n=20)were assayed.The relationship of these indices with the urine albumin excretion rate(UAER)was discussed.Results The concentrations of plasma 8-epi-prostaglandin F_~2α and DH-TXB_2 in DN patients were significantly increased more than those in normal controls.Those indicators in clinical diabefic nephropathy(CDN) patients ~increased more than those in early diabetic nephropathy(EDN).Plasma 6-keto-PGF_~1α level in patients with DN was lower than that in normal controls.While it was lower in CDN than that in EDN.The levels of plasma 8-epi-PGF_~2α and DH-TXB were positively correlated with UAER,while the concentrations of plasma 6-keto-PGF_~1α were negatively correlated with UAER.~Conclusion The injury of endothelial cell,oxidative stress and platelet ~activation may be one of the mechanisms for the DN.
出处
《江苏医药》
CAS
CSCD
北大核心
2005年第4期261-262,共2页
Jiangsu Medical Journal
