摘要
目的 探讨高血压病患者血压与胰岛素抵抗、血糖、血脂、尿酸水平的关系。方法 测定222例高血压病患者的收缩压、舒张压、心率;以稳态模式评估法计算胰岛素抵抗指数(HO- MA-IR);与胰岛素抵抗有关的指标:体重指数、腰围臀围比、口服葡萄糖耐量试验血糖曲线下面积(ACUG)、总胆固醇、甘油三酯。结果 106例2级高血压病人的HOMA -IR(1. 8±1. 4)显著高于116例1级高血压病人的HOMA -IR(1. 4±1. 2),两者比较P<0. 05。逐步回归分析显示,HOMA -IR与ACUG是收缩压的独立相关因素;体重指数、尿酸与心率是舒张压的独立相关因素。结论 高血压病患者收缩压和与胰岛素抵抗、血糖直接相关;舒张压与肥胖程度、尿酸及心率直接相关。
Objective To study the relationship between blood pressure and insulin resistance,blood glucose,blood lipid,uric acid in patients with essential hypertension.Methods systolic pressure,diastolic pressure,heart rate,body mass index,waist-hip ratio,area under curve of glucose after oral glucose tolerance test (ACUG),total cholesterol,triglycerides and uric acid were determined in 222 patients with essential hypertension.Homeostasis model assessment was applied to assess the status of insulin resistance (HOMA-IR).Results HOMA-IR was significantly higher in 106 patients with grade 2 hypertension than in 116 patients with grade 1 hypertension (P<0.05).A stepwise multiple linear regression analysis showed that HOMA-IR and ACUG were significant independent predictors of systolic pressure;body mass index,uric acid and heart rate were significant independent predictors of diastolic pressure. Conclusion systolic pressure is directly related to insulin resistance and blood glucose and diastolic pressure is directly related to obesity,uric acid and heart rate in patients with essential hypertension.
出处
《临床内科杂志》
CAS
2005年第4期262-264,共3页
Journal of Clinical Internal Medicine
关键词
血压
胰岛素抵抗
高血压病
Blood pressure
Insulin resistance
Hypertension
