摘要
目的:探讨小鼠结肠组织Cajal间质细胞超微结构及其与肠神经系统的关系。方法:用透射电镜观察健康成年雄性ICR小鼠结肠组织Cajal间质细胞的超微结构、分布及其与肠神经系统的关系。结果:小鼠结肠组织Cajal间质细胞主要结构特点:细胞呈纺锤形,有巨大的卵圆形核及向外伸展的长突起,胞质内有丰富的线粒体、大量光面内质网和粗面内质网;环肌层和纵肌层内Cajal间质细胞与肠神经元之间形成突触样连接,Cajal间质细胞突起包绕神经纤维。结论:Cajal间质细胞具有独特的超微结构,其与肠神经系统解剖与结构上的特殊关系可能是Cajal间质细胞调节多种胃肠功能的基础。
Objective:To study the ultrastructure characters of interstitial cells of Cajal(ICC) and the relationship between ICC and the enteric nerves in mice colon. Methods:Tissues of male adult ICR mouse colon were observed with conventional electron microscopy, including their ultrastructure, distribution of ICC and the relationship between ICC and the enteric nerves. Results:ICC were characterized by long processes, large oval nuclei and scant perinuclear cytoplasm. The cytoplasm contained numerous mitochondria, abundant smooth and rough endoplasmic reticulum. ICC in the circular muscle layer and longitudinal muscle layer of mice colon formed synaptic-like contacts and their processes were often associated with neighboring nerve trunks. Conclusion:ICC in colon have unique ultrastructure characters and these cells form specialized junctions with enteric nerves system, which maybe the basis of ICC mediating the gastrointestinal function.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2005年第5期328-329,340,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省"135工程"重点人才基金
江苏省自然科学基金资助项目(BK2004158)
