摘要
[目的 ]探讨血清可溶性细胞间黏附分子 - 1(sICAM - 1)和P选择素 (sP -selectin)水平与冠心病活动性间的关系。 [方法 ]用ELISA法测定 19例稳定型心绞痛 (SAP)、18例不稳定型心绞痛 (UAP)、13例急性心肌梗塞 (AMI)患者血清sICAM - 1和sP -selectin浓度 ,进行统计学分析。[结果 ]AMI组血清sICAM - 1、sP -selectin浓度高于UAP组 ,UAP组血清sICAM - 1、sP -se lectin浓度高于SAP组 (sICAM - 1在 3组中比较P值均 <0 .0 0 1;sP -selectin在AMI组与SA组P <0 .0 0 1,UA组与SA组比较P =0 .0 3,AMI组与UA组P =0 .0 2 ,均有显著性差异 )。方差分析表明 ,血清sICAM - 1及sP -selectin浓度均与冠心病的活动性呈现正相关。 [结论 ]sICAM - 1、sP -selectin浓度与冠心病的活动性有关。
Objectives] To investigate the relation between the changes of serum soluble intercellular adhesion molecule -1(sICAM-1);P-selectin (sP-selectin)and the activity of coronary heart disease(CHD). [Methods] The concentrations of serum sICAM-1 and sP-selectin were evaluated by means of enzyme linked immunosorbant assay (ELISA) in 19 patients of stable angina pectoris(SAP),18 patients of unstable angina pectoris(UAP), and 13 patients of acute myocardial infarction(AMI). [Results] The concentrations of serum sICAM-1 and sP-selectin were higher in AMI than those in UAP, and significantly higher than those in SAP(sICAM-1 :P<0.001;sP-selectin:SAPvsUAP P=0.03,SAPvsAMI P<0.001,UAPvsAMI P=0.02) [Conclusion] The concentrations of serum sICAM-1 and sP-selectin were correlated with the activity of CHD.
出处
《大连医科大学学报》
CAS
2005年第1期16-18,共3页
Journal of Dalian Medical University
关键词
冠心病
细胞间黏附分子
P选择素
coronary heart disease
soluble intercellular adhesion molecule
soluble P-selectin
