摘要
目的 探讨抑郁症状中学生自动思维与血清细胞因子水平的关系。方法 用问卷法、放射免疫法检测49名 抑郁症状中学生和32名正常中学生的抑郁程度、血清白细胞介素(IL) 2、IL-6、IL-8和肿瘤细胞坏死因子- α(TNF- α)。结果 ①抑郁症状中学生的血清IL-2、IL-6、TNF-α水平显著低于正常对照组;②抑郁症状中学生血清TNF- α、IL-2和IL-6与 Beck、Zung氏抑郁总分和自主思维总分呈显著的负相关,与IL-8呈显著的正相关;③Beck抑郁量表和负性自主思维量表中 的部分因子与血清IL-2、IL-6,TNF-α水平呈负相关。结论 青少年抑郁症状伴有免疫抑制的表现,可能存在与临床抑郁症 不同的免疫学机制。
Objective To explore the relationship between cognition and serum cytokines in middle school students with depressive symptoms. Methods The serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) were measured in 49 middle school students with depressive symptoms and 32 normal controls by adopting scales and radioimmunology methods. Results ①The serum levels of IL-2, IL-6, and TNF-α in middle school students with depressive symptoms were significantly lower than those in the controls. ② Serum levels of IL-2, IL-6, and TNF-α in depressive subjects were negatively correlated with the total scores of Beck, Zung and Automatic Thoughts Questionnaire (ATQ), but serum IL-8 levels were positively and significantly correlated with total Beck, Zung and ATQ scores. ③ Serum levels of IL-2, IL-6, and TNF-α were correlated negatively with Beck and ATQ factors. Conclusion Depressive symptoms in middle school students are accompanied by signs of immunosuppression. The immunological mechanisms may be different from the clinical major depression.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2005年第5期454-457,共4页
Journal of Third Military Medical University
基金
国家社会科学基金资助项目(OOBSH025)~~
关键词
中学生
抑郁症状
白细胞介素
细胞因子
middle school student
depressive symptom
interleukin
cytokine
