摘要
目的 探讨肝静脉阻塞型布加氏综合征的发病机制和合理的治疗方案。方法 将2 0条杂种犬随机等分为实验组和对照组,在自动控制X光机监视下,利用介入技术将带侧孔的球囊导管分别放入肝左静脉和肝右静脉,球囊远端阻塞肝静脉远端后,实验组分别注入无水乙醇、明胶海绵和钢丝圈,对照组注入生理盐水。饲养5个月后在全身麻醉下,测定肝功能和门静脉压力,并行肝脏活检,与未行本项操作的家犬门静脉和肝脏组织进行比较。结果 实验组均出现肝静脉闭塞或严重狭窄,出现胃底食管静脉曲张、瘀血性肝硬变,而对照组正常,实验组和对照组总胆红素(TB)分别为(3 1.6±2 .1)和(13 .7±1.1) μmol/L、丙氨酸氨基转移酶(ALT )分别为(15 6.2 3±17.67)和(2 8.44±3 .12 )U /L、碱性磷酸酶(AKP)分别为(177.89±11.2 2 )和(5 8.3 3±17.2 3 )U /L、白蛋白(ALB)分别为(4 0 .3 3±5 .10 )和(5 5 .3 2±4.10 ) g/L及门静脉压力(HPP)分别为(2 5 .68±2 .10 )cmH2 O和(11.5 6±1.70 )cmH2 O ,差异均有统计学意义(P <0 .0 1)。
Objective To investigate the pathogenesis and the rational therapy for Budd-Chiari syndrome with hepatic venous stenosis.Methods The 20 hybrid dogs were selected and divided into experimental group and control group.Being monitored by autocontrol X-ray apparatus under the general anaesthesia,the balloon catheter was sent to the right,middle hepatic vein respectively through internal jugular vein.Twenty ml absolute ethyl alcohol,the sponge,the wire loop were injected in the experimental group,while 20 ml normal saline was injected in the control group.Five months later,liver function was tested and hepatic portal pressure measured,and liver biopsy was performed under general anaesthesia.Results The signs of portal hypertension and the congestive cirrhosis with hepatic venous stenosis or severest stricture occurred in experimental group.The levels of total bilirubin in experimental and control groups were (31.6± 2.1) μmol/L and (13.7± 1.1) μmol/L,alanine aminotransferase (156.23± 17.67) U/L and (28.44± 3.12) U/L,alkaline phosphatase (177.89± 11.22) U/L and (58.33± 17.23) U/L,albumin (40.33± 5.10) g/L and (55.32± 4.10) g/L,hepatic portal pressure (25.68± 2.10) cm?H 2O and (11.56± 1.70) cm?H 2O respectively,with all the differences being statistically signficant ( P < 0.01). Conclusion The Budd-Chiari syndrome model with hepatic venous stenosis can be established with this method.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2005年第4期494-495,共2页
Chinese Journal of Experimental Surgery
