摘要
抗病毒药物２，５，６-三取代－４（３Ｈ）嘧啶酮衍生物的合成及诱导干扰素活性刘新泳，徐丽君（山东医科大学药学系济南２５００１２）取代嘧啶酮类化合物是一类小分干扰素诱导剂，有抗病毒、抗肿瘤、杀菌抑霉、诱导干扰素和白介素、免疫调节等多种生物活性（１）。目前?..
In order to search for more ideal antiviral
drugs,21 substituted pyriiT1idinone derivatives were designed and
synthesized,among which 11 were not reported before. The
cheinicalstructures were characterized by elemen tal and spectral
analysis. The serum interferon - inducing activity was tested in
mice. All 2-amino-5-bromo-6-substituted-4-(3H)pyrimidinone compounds
were shown to have interferon inducing activity.The corresponding
substituted pyrimidine thiones were less active.The new compounds of
6-sulfophenyl derivatives are soluble in、water, but the
interferon-inducing activity are not higher than the original
compound of ABPP.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第2期153-157,共5页
Acta Pharmaceutica Sinica
关键词
抗病毒药
嘧啶酮
干扰素
诱导剂
Antivirus
Interferon Inducing
agent
Pyrimidinone
