摘要
目的探讨原发性乳腺癌患者哨兵淋巴结活检(SLNB)后,哨兵淋巴结(SN)转移者非哨兵淋巴结(NSN)转移相关的临床及组织学因素。方法252例确诊为原发性乳腺癌患者SLNB后行腋窝淋巴结清扫,所有的腋窝淋巴结(SN及NSN)均行常规组织学检查。应用字2检验分析年龄,肿瘤大小,肿瘤位置,病理类型,受体状态和SN转移数目与NSN转移的关系。结果SLNB成功率94%,假阴性率7.4%。随着原发肿瘤的增大,NSN转移的可能性增加:T1a+T1b期肿瘤NSN转移率为0;T1c期为42%;T2期为87%。只有1个SN转移的患者NSN转移率明显低于多个SN转移的患者(27%vs46%)。结论NSN转移的可能性随着原发肿瘤的增大和多个SN转移而增加,而患者的年龄,肿瘤的位置,病理类型和受体状态不影响NSN转移的可能性。
Objectives To investigate the clinic and histological factors of NSN metastatic correlation of SN metastasis after SLNB for breast cancer. Methods 252 patients underwent axillary dissection after SLNB. All lymph nodes (including SN and NSN) were evaluated by routine histologic examination. The patients′ age, primary tumor sizes, histologic type, tumor Location, and hormone receptors, and relationship between metastatic number and NSN metastasis were analyzed by ?字2 test. Results The successful rate of SLNB was 94%. The false-negative rate was 7.4%. With increasing tumor size, NSN metastases might be increased. The incidence of NSN metastases in patients with T1a+T1b tumors was 0,T1c was 42% and T2 87%. In the patients with a single positive SN, NSN metastatic rate less than that multiple SN metastasis(27% vs 46%). Conclusion Increasing tumor size and the number of positive SN was correlated with increasing likelihood of positive NSN. It may be no relationship between the metastases of NSN and age, tumor location, histologic type, and hormone receptors.
出处
《岭南现代临床外科》
2005年第1期12-14,共3页
Lingnan Modern Clinics in Surgery
基金
广东省科委攻关资助项目(99M04914G)
