摘要
目的:了解复发性外阴阴道念珠菌病(RVVC)临床分离菌株及其对几种常见抗真菌药物的敏感性。方法:分别采用念珠菌显色培养基和ROSCO纸片扩散法进行RVVC念珠菌菌种鉴定和药敏试验。结果:62株阳性标本中,分离出白念珠菌47株(75.81%),热带念珠菌4株(6.45%),光滑念珠菌2株(3.23%),克柔念珠菌5株(8.06%),其他念珠菌4株(6.45%)。62株念珠菌对4种常用的抗真菌药物,即两性霉素B、酮康唑、氟康唑和伊曲康唑的敏感率分别为:100.00%(62/62)、88.71%(55/62)、96.77%(60/62)、95.16%(59/62)。结论:RVVC的主要致病菌仍是白念珠菌,但非白念珠菌所占比例呈上升趋势;RVVC分离菌株对咪唑类抗真菌药物仍有较高的敏感率。
Objective: To investigate the species of the clinical isolates and the susceptibility of Candida spp. to antifungal agents in recurrent vulvovaginal candidiasis(RVVC) patients. Methods: CHROM agar Candida was applied to isolate non-Candida albicans strains from Candida albicans. ROSCO Neo-Sensitab disk diffusion was used for yeast susceptibility testing. Results: In the 62 isolates there were 47 Candida albicans(75.81%), 4 Candida tropicalis(6.45%), 2 Candida glabrata(3.23%), 5 Candida krusei(8.06%) and 4 other Candida spp(6.45%). Drug susceptibility rates of the strains to amphotericin B, ketoconazole, fluconazole, itraconazole were 100%(62/62), 88.71%(55/62), 96.77%(60/62), 95.16%(59/62) respectively. Conclusions: C.albicans is still the major pathogen in the RVVC cases; the clinical isolates from the RVVC cases are still highly sensitive to azoles.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2005年第4期215-217,共3页
Journal of Clinical Dermatology
