摘要
目的 探讨低度恶性子宫内膜间质肉瘤(LESS)的临床病理学特征、诊断和鉴别诊断。方法 分析17例LESS的临 床病理特点,通过网织纤维染色、免疫组化染色和电镜观察来研究其病理学特征。结果 LESS临床上主要表现为阴道不规则 流血。HE染色见肿瘤组织成巢团样浸润,肿瘤细胞圆形、卵圆形或梭形。肿瘤内有大量的小血管。网织纤维染色见网状纤 维丰富,围绕瘤细胞生长。肿瘤细胞14例CD10阳性,12例ER阳性,13例PR阳性,3例actin阳性,CD34、CD117、Melan A肿 瘤细胞均阴性。电镜观察见肿瘤细胞胞质内的中间丝呈杂乱无序的排列。结论 LESS易误诊,确诊主要依靠组织病理学和 免疫组织化学;病理形态上看似良好的低度恶性子宫内膜间质肉瘤,预后不一定好。
Purpose To study the clinical features and differential diagnosis of low-grade endometrial stromal sarcoma. Methods Seventeen cases of low-grade endometrial stromal sarcoma were observed by histologic and immunohistochemical staining,in which two cases were studied by electron microscopy. Results The main clinical symptom of these patients was irregular vaginal bleeding. Microscopically,round,oval or spindle tumor cells composing the nest invaded around tissues. There were a lot of blood vessels in the tumor. Abundant reticulin distributed between tumor cells. Immunohistochemically,14 cases positive for CD10,12 for ER,13 for PR and 3 for actin were detected,but no tumor cells were positive for CD34,CD117 or Melan-A. Ultrastructurally,intermediate filaments of the tumor cells arrayed unorderly. Conclusions Low-grade endometrial stromal sarcoma is easily mistaken for other tumors by clinical doctors. The diagnosis relies mainly on histopathological and immunohistochemical findings. It is strange that some cases seem morphologically benign but are prognostically malignant.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2005年第1期58-61,共4页
Chinese Journal of Clinical and Experimental Pathology
