摘要
哈伯因是一种外周和中枢系统的高效可逆的胆碱酯酶抑制剂 ,且对红细胞乙酰胆碱酯酶有特异选择性 ,从而保留了血浆丁酰胆碱酯酶对有机磷毒剂的清除能力 ,并能透过血脑屏障 ,对脑组织乙酰胆碱酯酶也有保护作用 ,实验证实它对急性有机磷中毒所致的中枢神经系统的不可逆性病理损害显示出良好的预防效果。本文介绍了哈伯因预防有机磷中毒的实验观察结果 ,作用机制及应用价值的研究进展。
Currently, it is a concerned project in medicine to study the effectiv e methods for treatment of organophosphate(OP) poisoning. Huperzine A is a poten t, reversible red cells acetylcholinesterases(AChE) inhibitor, which shows high specificity for AChE preserving scavenger capacity of plasma butyrylcholinester ase(BuChE) for OP agents, and cross the blood-brain barrier smoothly preventing the AChE in CNS, so the CNS damages induced by the acute OP poisoning were preve nted. These review summarizes the results of experimental in animals, prevention mechanism, and prevention value of HupA against OP poisong.
出处
《卫生研究》
CAS
CSCD
北大核心
2005年第2期224-226,共3页
Journal of Hygiene Research
基金
国家"十五"科技攻关计划课题 (No .2 0 0 1BA70 4B0 6)
关键词
有机磷酸酯中毒
哈伯因
乙酰胆碱酯酶
organophosphate poisoning, huperzine A, acety lcholinesterases
