摘要
目的:探讨人类白细胞抗原DRB1(HLA-DRB1)等位基因多态性与慢性乙型肝炎发生的相关性。方法:采用序列特异性引物聚合酶链反应技术(PCR-SSP),检测126例慢性乙型肝炎患者和76例健康对照的HLA-DRB1*03、*07、*09、*12、*15等位基因,并进行分析。结果:HLA-DRB1*07在慢性乙型肝炎组的等位基因频率明显高于对照组(P<0.05)。结论:HLA-DRB1*07与慢性乙型肝炎的发生呈正相关,可能是慢性乙型肝炎的易感基因。
Objective: To investigate the correlation between chronic hepatitis B and the HLA-DRB1 alleles. Methods: HLA-DRB1*03, *07, *09, *12, *15 alleles in 126 patients with chronic hepatitis B and 76 normal control subjects were determined by PCR amplification with sequence-specific primers(PCR-SSP). Results: The frequences of HLA-DRB1*07 in the chronic hepatitis B group were significantly higher than those in the normal control group (P<0.05). Conclusion: HLA-DRB1*07 al-lele is closely associated with the susceptibility to chronic hepatitis B, and may be the susceptible gene.
出处
《山东大学学报（医学版）》
CAS
北大核心
2005年第3期267-269,共3页
Journal of Shandong University:Health Sciences
