摘要
目的探讨不同ABO血型的各型肝病患者体液和细胞免疫指标改变状况。方法应用免疫扩散和APAAP桥联酶标等方法,检测健康对照组(NC)500例、乙肝标志物阳性的各型肝炎562例,分别测定体液及细胞免疫功能。结果各肝病组与NC组相比,体液免疫指标改变明显,自ASC至PHC,IgE递增显著,IgD、IgG次之,PHC组C3、CIC明显升高,ERFC明显降低。AB血型的肝病IgG、IgE、C3、CIC明显升高,ERFC显著降低,AB血型的LC和PHC患者CD4+、CD4+CD8+明显降低,与其他各血型组和NC组相比,有显著性差异(P<005)。结论在HBV感染者中,AB血型者易于发生LC和PHC,这一血型的肝病患者易出现体液免疫亢进和细胞免疫功能不足。
Objective:To investigate the changes of humoral and cellular immunity markers in various liver disease by ABO blood group,the reliable evidences were provided.Methods:The cases of 500 health men (NC) as contrals,various acute and chronic liver disease with the positive index of hepatitis B which include acute hepatitis (ASC) 140 cases,chronic hepatitis (CH) 192 cases,post-hepatitis cirrhosis (LC) 160 cases,primary hepatocellular carcinoma (PHC) 70 cases were examined by immune-spresding assay,APAAP immune-bridge assay and so on in the study,the changes of serumal IgG,IgM,IgA,IgD,Ige,complement C_3(C_3),total complment (CH50),circulatory,immune complex (CIC),E-rosetter formation rate (E-RFC) and T-lymphocyte subsets in the group of NC,ASC,CH,LC and PHC were investigated respectively. Results:Compared to contrals,the humoral immune markers of all groups of liver disease changed markedly,Ige increased changed apparently and IgG increased.Secondly from ASC,CH,LC, to PHC,mean while,C_3 and CIC increased obviously and E-RFC decreased obviously in the group of PHC.Compared to the group of other blood type incresed markedly (P<0.05),whose E-RFC decreased markedly (P<0.05),CD4+,CD4+/CD8+ of LC and PHC diseases with AB blood type also decreased markedly (P<0.05).Conclusion:These findings showed that the patients with AB blood type suffer from LC and PHC easily in the HBV-infected population and who have got hyper-humoral immune function and hypo-cellular immune function easily. [
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2005年第3期226-229,232,共5页
Chinese Journal of Immunology
