摘要
目的:观察单纯高脂血症患者红细胞左旋精氨酸(L-Arg)转运及一氧化氮的变化。 方法:高脂血症患者12例(高脂组)和健康者12例(对照组)。两组在年龄、性别上匹配。空腹取血测定血脂水平、血浆亚硝酸盐(NO2-)含量;以3H-L-Arg测定红细胞L-Arg转运。 结果:高脂组血浆中NO2-水平为对照组的4.7倍(P<0.01),高脂组红细胞L-Arg最大转运速率(Vmax)较对照组增加33％(P<0.01),其中y+载体介导Vmax增加47％(P<0.01),而总转运、y+载体介导转运亲和力(Km)无明显变化(P>0.05);y+L载体介导转运与对照组差异无统计学意义(P>0.05)。 结论:高脂血症时红细胞L-Arg/一氧化氮系统发生异常改变。
Objective:To study the changes and clinical significance of L-arginine/nitric oxide pathway of erythrocyte in patients with hyperlipidemia.Methods: twelve patients with hyperlipidemia and 12 healthy humans with age matched were divided into two groups, blood samples were taken to measure the level of serum lipid, to measure the L-Arg transport of erythrocyte with 3 H-labelled and the content of nitrite in serum.Results: (1)Serum Nitrite in hyperlipid group is higher than that in control by 4. 7 times (p<0. 01). (2)The Vmax of total transport of L-Arg and via y + system in hyperlipid group is increased by 33% and 47% compared with that in control(p <0. 01 respectively). But Km of total transport and via y + system has no change(p > 0. 05 ) , the Vmax of transport and Km via y + L system has no significant difference between two group(p >0. 05).Conclusion: Hyperlipidemia could result in the abnormality of L-Arginine transport and nitric oxide production.
出处
《中国循环杂志》
CSCD
北大核心
2005年第1期48-50,共3页
Chinese Circulation Journal
基金
国家教委科研基金
国家自然科学基金资助课题(编号:39730220)
