摘要
目的 初步观察神经生长因子(NGF)联合强化铁营养(FIN)防治爆震性聋的近期临床效果。方法 将参加实弹演习的200例炮手分为NGF组(48例,于射击前14 d至射击后14 d肌肉注射NGF)、FIN组(62例,射击前14 d至射击后14 d口服临床常规用药剂量1倍的硫酸亚铁片剂)、联合应用NGF和FIN组(56例,射击前14d至射击后14 d肌肉注射NGF,口服临床常规用药剂量1倍的硫酸亚铁片剂)及空白对照组(34例)。测定爆震前和爆震后1、7、14 d的纯音测听值,以及爆震前、爆震后14 d畸变产物耳声发射(DPOAE)值。结果 爆震后1 d:NGF组有1例(2.1%,1/48例)出现轻度听力异常(轻度聋),FIN组有2 例(3.2%,2/62例)出现轻度听力异常(轻度聋),联合用药组无听力异常出现,对照组有6例(17.6%,6/34例)出现听力异常(其中2例为轻度聋、2例为中度聋、1例为中重度聋、1例为重度聋)。爆震后7 d:NGF组和FIN组听力异常者听力均恢复正常,对照组无听力明显好转者。爆震后14 d:对照组中有1例轻度听力异常者听力恢复正常,余无明显好转,与其他3组间的差异均有显著性;爆震前对照组DPOAE幅值和信噪较其他3组明显下降,差异有显著性。结论 NGF联合 FIN对爆震性聋有明显的防治作用。
Objective To study the protective effects of nerve growth factor (NGF) combined with fortified with combiron nutrition (FIN) on blast exposure hearing damage. Methods 200 soldiers were randomized into four groups: NGF group (n=48, NGF were injected intrameularly); FIN group (n=62 cases,FeSO 4 tablets were given orally); Combination group (n=56, were given NGF combined with FIN), and the blank control group (n=34). The former three groups received the corresponding each drug 14 days before and after the exposure.The pure-tone audiometry(PTA) was carried out before and 1 d, 7 d, 14 d after the exposure. The DPOAE was also carried out before and 14 d after the exposure. Results The PTA showed 1 d after the exposure: 1 had slight hearing damage in the NGF group, 2 in the FIN group, but none in the combination group,6 showed more hearing damage in the control group. 7 d after exposure: the slight hearing damage remained in the NGF group and recovered in FIN group but no change in the control group. 14 d after exposure : 1 slight hearing damage in the control group recovered, no improvement was noticed in the others; the DPOAE in the control group decreased more than those in the other three groups, The differences were significant. Conclusion NGF combined with fortified iron nutritional diet can obviously protect cochlear apparatus against blast exposure.
出处
《上海医学》
CAS
CSCD
北大核心
2005年第2期140-143,共4页
Shanghai Medical Journal
基金
中国人民解放军"十五"医药卫生青年基金资助项目(2001Q090)
