摘要
目的 探讨尿毒症患者体内血清甲状腺激素的变化以及血液透析对其的影响,为临床的诊治提供依据。方法 尿毒症患者分为非血液透析组(A组,30 例)和血液透析组(B组,20 例),用化学发光的方法测定其血清甲状腺激素包括TT3、TT4、FT3、FT4、TSH;在血液透析组中有10 例患者(C组)血液透析前后测定其血清甲状腺激素;并测定了20例年龄、性别相匹配的健康人群的血清甲状腺功能作为对照组(CG)。结果 尿毒症患者与对照组比较,TT4、FT3、FT4 均下降,两组数据比较,差异有显著意义,其余差异无显著意义。血液透析前后比较甲状腺激素各项指标差异无显著意义。非血液透析组中BUN、Scr与FT3、FT4 呈负相关,与TSH无相关性。结论 在尿毒症患者有较高频率的甲状腺功能减退,在终末期肾脏疾病的患者中检测甲状腺功能应作为常规。
Objective To investigate the changes of throid function and the effects of undergoing hemodialysis(HD) in uremic patients,so as to provide the evidence for the clinical treatment and diagnosis.Methods Serum concentrations of total triiodothyronine(TT_3),total thyroxine(TT_4),free thyroxine(FT_4) and free triiodothyronine(FT_3),measured by enhanced chemiluminescence immunoassay,and thyroid-stimulating hormone(TSH) were compared in undialysed(n=30),haemodialysed patients(n=20) and sex-,age- matached healthy controls(n=20),and in ten haemodialysed patients before and after haemodialysis.Results Serum TT_4,FT_3,FT_4 concentration was significantly lower in uremic patients than that in healthy controls.Serum concentrations of TT_4 and TSH were seen the same as the two groups.Serum concentrations of thyroid hormones were not different in haemodialysed patients before and after haemodialysis.The negative correlation was detected between blood urea nitrogen and creatinine and FT_3,FT_4 in undialysed patients,but not TSH.Conclusion Because of the high incidence of hypothyroidism in uremic patients,screening of thyroid function should be considered to be a routine examine in evaluation of end-stage renal disease patients.
出处
《中国基层医药》
CAS
2005年第3期301-303,共3页
Chinese Journal of Primary Medicine and Pharmacy
