摘要
目的 探讨血浆同型半胱氨酸 (Homocysteine ,HCY)水平与脑卒中之间的关系。方法 检测健康人与脑卒中患者的血浆HCY水平 ,统计高HCY卒中患者与正常HCY卒中患者伴随的脑卒中危险因素状况 ,进行对比分析。结果 脑卒中组HCY水平(2 8 2 4± 6 62 ) μmol/L ,对照组 (9 16± 2 3 4) μmol/L ,有显著差异 (P <0 0 5 ) ;脑卒中组高HCY血症发生率 3 8% ,对照组 5 % ,有显著性差异 (P <0 0 1)。高HCY卒中患者与正常HCY卒中患者伴随的吸烟、高血压病、糖尿病及高血脂症的状况无显著性差异 (χ2 =0 3 8,0 0 8,0 47,1 0 8;P >0 0 5 )。结论 脑卒中患者血浆HCY水平升高 ,高HCY血症是脑卒中的独立危险因素。
Objective To explore the relation between plasma homocysteine concentration and stroke. Methods Subjects with stroke (n=140) and healthy control subjects(n=40 ) were measured the plasme homocysteine concentration, the risk factors of stroke in patients with high homocysteine concentration and normal were analyzed. Results Plasma homocysteine concentration in the stroke patients (28.24±6.62)μmol/L were higher than that in the controls (9.16±2.34)μmol/L. The incidence of hyperhomocysteinemia in the stroke patients (38%) was obviously higher than that in controls (5%).As compared with the normal, there were no significant differences in stroke risk factors ,such as cigarette、smoking、hypertesion、diabetes and hyperlipidemia of stroke patients with high homocysteine (χ 2=0.38,0.08,0.47,1.08,P>0.05) .Conclusion The plasma homocysteine concentration is increased in stroke, plasma homocysteine concentration as a independent risk factor of stroke.
