摘要
目的:为了解NSAID引起的胃肠道副作用 。方法:分析1986—1992年因其所致上消化道出血226例。结果:住院比例逐年增高,56.2％发病前无症状,35.4％和14.2％,9例穿孔;69.9％为急性胃十二指肠粘膜麋烂、应激性溃疡出血,30.1％为慢性溃疡出血。结论:①诱发急性慢性溃疡:②不论年龄、使用时间长短均可发生胃十二指肠粘膜损害致严重并发症。
AIM To investigate the side effects on nonsteroidal anti-inflammatory drugs(NSAID)on gastrointestinal tract.METHODS A retrospective method was used to analyse 226 cases of the upper gastrointestinal bleeding caused by NSAID from 1986to 1992.All the cases were confirmed by endoscopy or surgical operation.RESULTS The hospitalization rate increased year by year.56.2% cases were as ymptomatic as befor attacks.The rates of mild,moderate and severe bleedimg and shock were 28.3%,36.3%,35.4% and 14.2% respectively.The cases with perforation were 9,the rats with acute gastroduodenal mucosal erosion and stress ulcer bleeding and with chronic ulcer bleeding were 69.9 % and 30.1 %separately.CONCLUSIONS(1)NSAID may induce acute and chronic ulcer,(2)Gastroduodenal mucosal erosion and sever complications occur inpatients on NSAID therapy no matter how the patients are and how long they had taken NSAID.
关键词
非甾类抗炎药
上消化道出血
分析
nonsteroidal anti-inflammatory drugs (NSAID) upper gastrointestinal bleeding mucosal erosion ulcer perforation
