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血清PSA的影响因素 被引量:9

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摘要 前列腺特异性抗原(PSA)是由前列腺上皮及尿道旁腺上皮所产生的蛋白酶,它的作用是液化精液.1980年在血中检测到了PSA,但到目前为止它进入血液循环的机制尚不清楚.1991年Stenman首次报道了血清中存在不同分子形式的PSA,游离态的PSA(fPSA)和复合态的PSA(cPSA),fPSA是PSA的酶原形式或是PSA的部分分解产物,具有免疫活性,可用免疫法测出.cPSA是与血清中多种蛋白酶抑制剂结合的PSA,主要包括与α1~抗糜蛋白酶形成的复合物(PSA~ACT)和与α2巨球蛋白形成的复合物(PSA~MG).PSA~ACT具免疫活性可用免疫法测出,PSG~MG不具免疫活性不能用免疫法测出.目前血清PSA、fPSA检测已普遍应用于前列腺癌的诊断,鉴别诊断,治疗效果监测,但是血清PSAfPSA受到一系列因素影响,同时血清PSA的诸多影响因素也引起了一些学者的极大兴趣.本文就影响因素做一综述.
作者 高中伟
出处 《现代泌尿外科杂志》 CAS 2001年第2期60-62,共3页 Journal of Modern Urology
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