摘要
目的:研究氧化低密度脂蛋白(OX-LDL)水平和对氧磷酯酶-1(PON-1)活性对动脉粥样硬化性血栓性脑梗死(ATCI)的致病和保护意义。方法:对146例ATCI患者(ATCI组)应用ELISA双抗体夹心法测定血清OX-LDL水平,紫外分光光度法测定血清PON-1活性,同时测定其他血脂项目和血糖水平,并与105例健康体检者(对照组)比较。结果:ATCI组血清OX-LDL水平高于对照组(P<0.01),PON-1活性低于对照组(P<0.01),且ATCI组血清OX-LDL水平与TG、脂蛋白a犤Lp(a)犦、PON-1活性水平、年龄相关,且与梗死面积、部位有关;其PON-1活性亦与OX-LDL水平、年龄相关,且与梗死面积、部位有关。结论:血清OX-LDL水平的升高和PON-1活性的下降与ATCI有关,对此两者水平的监测和早期干预可能有助于预防ATCI的发生。
Objective To study the changes of serum OX-LDL level and the activity of PON-1 in arteriosclerotic thrombotic cerebral infarction ATCI individuals and learn their effects on ATCI. Methods The levels of serum OX-LDL and PON-1 activity were observed in 146 ATCI patients and 105 control individuals meanwhile blood lipid and FBG were also observed. Results The level of serum OX-LDL in ATCI was higher than that of control group P < 0.01 and the activity of PON-1 in ATCI was lower than that of control group P < 0.01. The serum OX-LDL level had correlations with TG Lap PON-1 age infarction area and infarction site. The activity of PON-1 had correlations with OX-LDL age infarction area and infarction site. Conclusion The rise of serum OX-LDL and the reduction of PON-1 activity might accelerate the processes of arteriosclerosis and ATCI. It is suggested that the control of levels of OX-LDL and PON-1 may prevent ATCI.
出处
《天津医药》
CAS
北大核心
2005年第3期151-154,共4页
Tianjin Medical Journal
