摘要
目的:评价体外循环改良超滤术对术后患者血清肿瘤坏死因子(TNF-α)、白细胞介素1β(IL-1β)含量的影响。方法:先天性心脏病患儿15例,在体外循环术后行改良超滤术,用ELISA法测定患儿术前、体外循环转流中主动脉开放5min后、超滤后、术后3、24h及超滤液中TNF-α、IL-1β含量;同时记录红细胞比容的(Hct)变化、术后引流量、输血量、呼吸机辅助时间。结果:TNF-α、IL-1β含量显著降低,超滤液中测出大量TNF-α、IL-1β,患儿术后引流量小,输血量少,呼吸机辅助时间显著缩短。结论:体外循环改良超滤术可显著降低患儿血清中TNF-α、IL-1β的含量,能有效预防及治疗体外循环术后全身炎症反应及脏器水肿。
Objective: To evaluate the effect of modified ultrafiltration technique during compulmonary bypass (CPB) on the level of TNF-α, IL-1β. Methods: Fifteen children with congenital heart disease(CHD) underwent modified ultrafiltration after CPB. The plasma levels of TNF-α, IL-1β before operation, during operation, after bypass, after modified ultrafiltration, 3 hours and 24 hours after operation were measured. At the same time, the changes of Hct, content of drain, content of blood transfusion, time of respirator done postoperatively were recorded. Results: TNF-α, IL-1β levels were significantly decreased by the ultrafiltration. The postoperative blood lose, the amount of transfused blood and the time of ventilator were significantly reduced. Conclusion: Modified ultrafiltration technique may effectirvly protect and treat systemic inflammatory response and organ edema after CPB.
出处
《山东大学学报（医学版）》
CAS
北大核心
2005年第2期124-127,共4页
Journal of Shandong University:Health Sciences
关键词
体外循环
心脏缺损
先天性
肿瘤坏死因子Α
白细胞介素1
Extracorporeal circulation
Heart defects, congenital
Tumor necrosis factor α
Interleukin-1
