摘要
目的 :观察豆根管食通口服液治疗食管癌的临床疗效及对其免疫功能的影响 ,并探讨其分子作用机制。方法 :采用随机、对照的方法 ,把符合标准的 6 0例食管癌患者分为对照组和治疗组各 30例 ,分别给予“豆根管食通口服液”和“替加氟片”治疗 ,重点观察治疗前后患者的一般状况、症状体征、生活质量、心电图、超声波、食管钡餐X片、血常规、肝肾功能、白介素 (IL -2、IL - 12 )、干扰素 (IFN -γ)、血清免疫球蛋白 (IgA、IgG、IgM)等的变化情况。结果 :治疗前后两组比较 ,其一般状况、症状体征、生活质量、临床疗效经各评分评定均有显著性差异 (P <0 .0 1) ,食管钡餐X片治疗前后达Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级标准比较有显著性差异 (P <0 .0 5 ) ,细胞因子比较有显著性差异 (P <0 .0 1,P <0 .0 5 )。结论 :豆根管食通口服液能明显改善食管癌患者的一般状况和症状体征、提高患者的生活质量、减轻患者的临床症状 ,能明显提高食管癌患者的血清IL - 2、IL - 12、IFN -γ及IgA、IgG、IgM的水平 ,提高机体的免疫功能等。
Objective: To observe the effect of Dougen guanshitong for treating Esophageal carcinoma and its effects on the immunology function of body, and to explore the pathogenesis. Methods: 60 patients meeting the standard were randomly divided into the control group and the treatment group which were treated respectively with the oral liquid and “tegafur”. The changes were then observed such as general condition, symptom, quality of live (QOL), electrocardiogram, ultrasonic wave, barium radiography of esophagus, blood routine examination, Cytokin (IL-2 and IL-12), interferon (IFN-γ)and immunity globulin (Ig series). Results: By comparison, general condition, KPS symptom, living standard and curative effect were improved obviously (P<0.01). barium radiography of esophagus were level Ⅰ, Ⅱ, Ⅲ and Ⅳ which were dramatically different (P<0.05). Cytokines of two groups were also improved obviously (P<0.05, P<0.01). Conclusion: The oral liquid can improve the general condition, symptom and quality of live (QOL) and improve the cell of immunity globulin (Ig series), interferon (IFN-γ), Cytokin (IL-2 and IL-12) and the immunity function of body.
出处
《河南中医学院学报》
CAS
2005年第2期31-33,共3页
Journal of Henan University of Chinese Medicine
基金
国家中医管理局资助课题 (编号 :0 2 - 0 3jp2 5 )
关键词
豆根管食通口服液
食管癌
生活质量
临床疗效
细胞因子
免疫功能
Dougen guanshitong Oral Liquid
esophageal carcinoma
quality of live (QOL)
curative
Cykotine
immunity function
