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MTA1与肿瘤侵袭转移的研究进展

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摘要 肿瘤转移相关基因 1(MTA1)是NuRD的亚单位之一,它通过促进组蛋白脱乙酰基,影响基因的转录和复制。研究发现,它与乳腺癌、食道癌、胃肠癌、胰腺癌等多种人类上皮源性肿瘤侵袭转移的能力紧密相关,它的高表达与肿瘤的侵袭深度与病理分级呈正相关,可作为评价预后的一个指标。
作者 陈元 王建军
出处 《国外医学(生理病理科学与临床分册)》 2005年第1期42-45,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 MTA1 NuRD 肿瘤转移
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