摘要
以中药芜荑的总提取物、水提取物和醇提取物对感染P.vinckei的小白鼠和醇提取物的两个层析组分C_0及C_3对人工培养的恶性疟疟原虫P.falciparum进行了疗效观察。结果总提取物显示一定疗效,给药第5天,其虫血症仅为对照组的1/5;醇提取物的效果十分显著,剂量提高到10mg/25g体重,每天两次腹腔内注射时,能在第5天完全消灭动物红细胞内的疟原虫。醇提取物的两个层析组分C_0及C_3在培养基中浓度达到10μg/ml时,亦能在第5天完全廓清培养基中红细腮内的疟原虫,其余层析组分C_1、C_2及C_4未见抗疟作用。
The extract of Pasta ulmi, including the whole extract, the lipophil extract and the water extract, was examined in mice infected with P.vinckei. Results suggested that the whole extract had some malariacidal effect, The lipophil extract in the dose of 10 mg/25 g body weight, given twice a day showed a totally malariacidal effect on the 5th day. The lipophil extract appeared to have a more powerful effect than the whole extract. The water diluted extract, however, produced no therapeutic effect at all. In the cell culture the isolated fraction of lipophil extract C1, C2, and C4 showed no inhibitory effect on P. falciparum, but the fraction C0 and C3 in a concentration of 10 μg/ml medium demonstrated a totally malariacidal effect on parasites on the 5th day of culture.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1989年第5期347-348,共2页
Acta Universitatis Medicinae Tongji
