摘要
目的:通过观察实验家兔血液流变学变化,探讨柴瓜消结汤治疗乳腺增生病的机理。方法:选用健康新西兰 家兔40只,随机分为空白对照组、模型对照组、柴瓜消结汤大、中、小剂量组,每组8只,采用苯甲酸雌二醇建立乳腺增 生动物模形,分别灌服不同剂量柴瓜消结汤生药提取液予以治疗,空白对照组灌服生理盐水,模型对照组灌服蒸馏 水。结果:模型对照组与空白对照组家兔相比,其全血粘度、血浆粘度、血沉比显著增加(P<0.05),而压积显著减少 (P<0.05):柴瓜消结汤各剂量组家兔全血粘度、血浆粘度、血沉和压积均回复到空白对照组正常水平,与模型对照组 相比差异显著(P<0.05)。结论:柴瓜消结汤可改变实验动物的血流变性,表明活血通络作用是柴瓜消结汤治疗和预 防乳腺增生病的机理之一。
Objective: To explore the mechanism of Chaiguaxiaoje Tang in treating hyperplasia of mammary gland through observing the blood rheology of experimental rabbits. Methods: 40 healthy Zelanian rabbits were selected and divided into blank control, model, different dose of Chaiguaxiaoje Tang groups with each 8 rabbits. The blood viscosity, plasma viscosity, blood sedimentation and HCT were observed. Results: The blood viscosity, plasma viscosity and blood sedimentation were increased in model control group compared with blank control group(P<0.05), but the HCT decreased (P<0.05). For different dose of Chaiguaxiaoje Tang groups, all the observed index had significant difference compared with model group (P<0.05), but had no difference compared with blank control group. Conclusion: Chaiguaxiaoje Tang can change the blood rheology of experimental rabbits. Activating blood and flowing venation is one of mechanism to treat and prevent hyperplasia of mammary gland.
出处
《中国计划生育学杂志》
北大核心
2005年第3期170-171,共2页
Chinese Journal of Family Planning
