摘要
目的探讨血浆脂质成份与冠状动脉病变支数和程度的相关性。方法对疑诊冠状动脉粥样硬化性心脏病(简称冠心病)而作选择性冠状动脉造影的220例住院患者,进行血浆脂质成份的测定。结果冠状动脉病变患者的载脂蛋白B、非高密度脂蛋白-胆固醇、低密度脂蛋白-胆固醇与高密度脂蛋白-胆固醇、甘油三酯与冠状动脉无病变组患者比较,差别均有显著性意义(均P<0.05);经Spearman相关分析和逐步多元回归分析表明冠状动脉病变支数与载脂蛋白B相关,病变程度与脂蛋白(a)相关。结论提示血浆脂质成份中的载脂蛋白B、脂蛋白(a)可能是冠心病发生与发展中的相关因素,并具有重要的致动脉粥样硬化的作用。
Objective To investigate the relationship between the lipid parameters of plasma and the severity of coronary artery lesions. Methods A total of 220 admitted patients were studied retrospectively, all patients were suspected to have coronary artery disease and underwent a selective coronary angiography and a survey of lipid parameters of plasma during the hospitalization. Results The plasma apoB, non-HDL-C and TG levels were significantly higher in patients with positive coronary angiography than those with negative results. The spearman correlation analysis and stepwise regression analysis showed a significant correlation between Lp(a) level and the severity of the coronary artery lesions, between apoB level and the number of involved vessels. Conclusions ApoB and Lp(a) level may be the most correlated factor with the development and progression of cardiovascular atherosclerotic disease.
出处
《浙江医学》
CAS
2005年第3期173-175,共3页
Zhejiang Medical Journal
