摘要
目的 为评价芬太尼多瑞吉 (Durogesic)透皮贴剂用于开胸手术后镇痛疗效、副作用和病人满意度 ,我们将其与我院沿用的皮下镇痛处方进行对比观察。方法 将 60例开胸手术病人分为 A、B两组 ,分别使用 5 mg剂型多瑞吉透皮贴剂和 10 0 m L型一次性镇痛泵配制芬太尼 (15 μg·m L - 1 )置管皮下 (皮下泵 )用于术后镇痛 ,比较其疗效、副作用和病人满意度。 结果 A组镇痛作用优于 B组 ,A组嗜睡病人较多 ,两组恶心、呕吐副作用类似 ,A组肛门排气较迟 ,但 A组病人满意度高 ,具有镇痛满意 ,使用方便、安全和便于活动的特点。
OBJECTIVE To evaluate the analgesic effect, side effect and satisfactory degrees in patients of Durogesic after thoracic surgery,compare it to the usual prescription of Subcutaneous PCA with fentanyl in our hospital.METHODS Sixty patients undergoing elective thoracic surgery under general anesthesia(ASA ⅠtoⅡ,BW>50kg)were assigned randomly into two groups:Group Durogesic(Group A,30 cases)and group scPCA(group B, 30 cases).The patients in group A were pasted Durogesic at 10 o' clock the night before operation. And the mixture of fentanyl 15μg·ml -1 was administered in group B after extubation.All PCA pumps for single use, background dose of 2ml·h -1 , bolus dose of 0.5mL,and lock-out time of 15 minutes,without loading dose. The following indexes were recorded VASF,RR,HR,SPO2,Ramsay scale,nausea, vomit,dizziness,pruritus at 2,8,24,48,72hours after operation,and finally recorded satisfactory degrees.RESULTS The VASF in group A at 2,8,24,48,72hours after operation was lower than group B(P<0.05),the Ramsay scale in group A at 2 hours after operation was higher than group B(P<0.05),the exhaust time in group A was later than group B(P<0.05),and the satisfactory degrees in group A was higher than group B(P<0.05).The side effect including nausea, dizziness,pruritus was no significant difference between group A and group B.CONCLUSION Durogesic has advantage when it is used as analgesic after thoracic operation, including effective, convenient, safe, slight side effect and no interference patient's activity,and patients likely to accept it.
出处
《海峡药学》
2005年第1期64-66,共3页
Strait Pharmaceutical Journal
