摘要
目的 应用基准剂量(BMD)方法来确定铅引起神经行为不良效应的血铅临界浓度。方法 对某蓄电池厂135名铅作业工人及143名非铅接触者进行WHO神经行为核心测试组合(WHO/NCTB)的测试。采用 BMD1 3 1软件中的Logistic模型计算BMD和BMD的95%可信区间下限(BMDL)。结果 血铅水平低于1 93μmol/L时,铅作业工人的积极情感(POMSV)、数字广度(DSP)、打点总数得分(PA)均明显低于对照组;当血铅水平高于 1 93μmol/L时,WHO/NCTB的各项指标除简单反应时(SRT)外均发生明显改变。卡方趋势检验证明除SRT、DSP指标外,WHO/NCTB指标的异常率与血铅水平之间存在着明显的关系。BMD的计算结果显示WHO/NCTB各项指标中最为敏感的是情感状态问卷(POMS)中的忧郁-沮丧(POMSD),其血铅BMD值和BMDL值分别为1 37μmol/L和1 17μmol/L。结论 情感状态问卷可作为评价铅接触引起神经行为功能损害的敏感指标。铅接触不引起神经行为功能损害的血铅接触限值为1 17μmol/L。
Objective Benchmark dose(BMD) was applied to determine the critical concentration of blood lead which led to adverse effects on neurobehavior. Methods 135 lead-exposed workers in one storage battery plant and 143 normal controls were tested with WHO neurobehavioral core test battery (WHO/NCTB). The logistic model in BMDS Version 1.3.1 was used to calculate BMD and the lower limit of BMD 95% confidence range(BMDL). Results The scores of positive mood states(POMSV), digital span(DSP)and pursuit aiming(PA) in lead exposure workers with blood lead<1.93μmol/L changed significantly; all indices in WHO/NCTB changed except simple reaction time(SRT) in lead exposed workers with blood lead≥1.93 μmol/L .The results of linear trend test indicated there was a significant dose-effect relationship between exposure dose (blood lead) and WHO/NCTB indices except SRT and DSP. The study on BMD showed that depression-dejection (POMSD) of profile of mood states(POMS) was the most sensitive among all indices of WHO/NCTB. The BMD and BMDL of blood lead were 1.37 and 1.17μmol/L respectively. POMS is much more sensitive than neurobehavior indices. Conclusion POMS can be regarded as a sensitive index in evaluating lead-induced neurobehavioral impairment. The critical concentration of blood lead for neurobehavioral damage is estimated to be 1.17 μmol/L.
出处
《中国职业医学》
CAS
北大核心
2005年第1期31-34,共4页
China Occupational Medicine
