摘要
目的:探讨多沙普仑在提高悬雍垂腭咽成形手术(UPPP)患者全麻苏醒期安全性的作用及意义。方法:36例ASAⅡ- Ⅲ级因阻塞性睡眠呼吸暂停综合征(OSAS)择期实施UPPP病人,随机分为两组:对照组(C组)和多沙普仑组(D组),每组18 例。所有病人均采用静吸复合全身麻醉,手术结束时停用全部麻醉药物,D组在手术结束时先静推多沙普仑1 mg·kg-1,继之静脉滴注0.1%多沙普仑+5%葡萄糖混合液;C组只在相应时间给予等量的5%葡萄糖液。记录手术结束至病人清醒和拔管时间以及拔管后6 h内MAP、HR变化和呼吸道并发症的发生情况。结果:与C组比较,D组病人清醒时间与拔管时间均明显缩短(P<0.05);拔管后6 h内病人MAP、HR较早恢复稳定,舌后坠、呼吸抑制、误吸、喉痉挛的发生率显著降低(P< 0.05)。结论:UPPP患者术后应用多沙普仑能降低全麻苏醒期的风险,具有安全、可靠、实施简便的特点,值得推广。
Objective: To investigate the effect and significance of doxpram on uvulopalatopharygoplasy ( UPPP) patients during awake period of general anesthesia. Methods: Thirty-six patients(ASA Ⅱ -Ⅲ ) of obstructive sleeping apnea syndrome (OSAS) undergoing UPPP were divided randomly into the control group (C group) and the doxpram group (D group). Balance anesthesia and direct nasal tracheal intubation were practiced in all patients. In group D, doxpram 1 mg/kg was injected intravenously at the end of operation and then mixture of 0. 1 % doxpram + 5% glucose dropped continously. But in group C. just 5% glucose was omkected intravenously. The recovery time and tube-withdraw time from the end of operation were recorded. The changes of HR,MAP and the incidence of airway complication within 6 hours after operation were monitored. Results: The awake time and tube-withdraw time was shorter in group D than that in group C(P<0. 05). The MAP and HR stabilized early after tube-withdrawing within 6 hours in group D compared to that in group C, while the incidence rates of glossocoma. respiratory depression, laryngospasm, aspiration were lower than that those in group C (P<0. 05). Conclusion: Doxpram administration earlier after UPPP can decrease the risk during awake of general anesthesia. It is a safe, reliable and easy to practice method.
出处
《中国临床医学》
北大核心
2005年第1期147-149,共3页
Chinese Journal of Clinical Medicine
